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Randomization,matching, and other techniques are employed to control for or minimize the impact ofconfounding variables, so that a cause–effect relationship between the intervention andoutcome can be established. It causes minimal or no dilatation of the smallerarteries such as of the intramyocardial coronary arteries. The use of advanced imaging approaches for early diagnosis and treatmentof acute ischemic stroke also facilitates implementation of early secondary prevention algo-rithms. Ithas been argued that high doses can reverse thebeneficial effects by concurrently inhibiting PGI2(antiaggregatory and vasodilatory) synthesis invessel wall

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C1 represents what the anesthetist would like to obtainfor the final concentration.

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